Australia begin new World Test Championship 2027 cycle in the West Indies without the pair.
Josh Inglis and Sam Konstas will come in for the pair for the Test that begins on June 25, the first match for both sides in the World Test Championship 2027 cycle.
A batting order and full Australian XI will be confirmed closer to the first ball.
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Australia talisman Steve Smith helps his side bounce back from early wickets with a fine half-century in the World Test Championship Final at Lord’s.
Smith’s finger injury sustained in the World Test Championship Final keeps him out of the team, though there are hopes of a return for the second Test in Grenada from July 3.
After a barren two-year run in Test cricket, Labuschagne was moved to up to open in the Lord’s Final, though made just 17 and 22 in the defeat to South Africa.
Chair of Selectors George Bailey confirmed the news of the changes on Friday morning.
“Steve needs more time for the wound to heal so we’ll give him another week’s rest and assess his functionality after that,” Bailey began.
“We have made the decision to give Josh and Sam the opportunity to replace Steve and Marnus. We are excited to see them get the chance to further their fledgling Test careers.”
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The incoming pair have impressed in their early outings, with Konstas turning heads in taking on World No.1 Test bowler Jasprit Bumrah and compiling a half-century on Boxing Day in Melbourne, and Inglis scoring a century on Test debut in Sri Lanka earlier this year.
With the pair given the chance to feature, Bailey also backed Labuschagne who remains a presence in the squad despite making way.
“Marnus at his best can be a really important member of this team. He understands his output hasn’t been at the level we, or he, expects.
“We will continue working with him on the areas of his game we feel he needs to rediscover. We continue to value his skill and expect him to work through the challenge positively.”
Australia Test squad: Pat Cummins (c), Sam Konstas, Usman Khawaja, Marnus Labuschagne, Cameron Green, Steve Smith, Josh Inglis, Travis Head, Alex Carey, Beau Webster, Mitchell Starc, Sean Abbott, Scott Boland, Josh Hazlewood, Nathan Lyon, Matt Kuhnemann.
West Indies Test squad: Roston Chase (c), Kraigg Brathwaite, Mikyle Louis, Brandon King, John Campbell, Shai Hope, Tevin Imlach, Justin Greaves, Keacy Carty, Jomel Warrican, Kevlon Anderson, Alzarri Joseph, Shamar Joseph, Johann Layne, Anderson Phillip, Jayden Seales
